@Eden_RichardsThe Queensland Cowboys have gone back-to-back in the Men’s Elite Eight after defeating the Queensland Titans 6-3 win at the National Touch League in Coffs Harbour.The reigning champions led the match from start to finish on a beautiful night at C.ex Coffs International Stadium, showing their class from the early minutes of play.It was an unfortunate result for the Titans who had performed so well for the whole tournament, but even they will appreciate the class and talent of the Cowboys’ side.A two-touchdown performance from Cormac Hoch helped his side to a 3-1 lead at half-time and they used this momentum to skip away in the second half. Jack Hughes opened the scoring in the early minutes of the second half, giving the Cowboys a commanding 4-1 lead in the process.They went on with it in the 27th minute, scoring the easiest of touchdowns through Damon Moore to lead 5-1.A stalemate emerged for the next seven minutes, before Cowboy Lachlan Hoch grabbed his first of the night to make it 6-1 with a little over five minutes to play.The Titans scored a consolation touchdown in the 36th minute to add some respectability to the scoreboard, but Graeme Clancy’s efforts were not enough, with the scoreboard showing a 6-2 scoreline in the Cowboys’ favour.Clancy grabbed a third touchdown on the hooter but the celebrations had already started for the Cowboys who held on for a 6-3 win.It was a complete 40-minute performance from the Cowboys who opened the scoring very early in the match to grab the upper hand from the get-go.In fact it took just three minutes for the Cowboys to cross the line, with Braydon Hegarty crossing in the left corner.Cormac Hoch sliced through the Titans’ defence in the 10th minute to make it 2-0, putting his side in a great position in the process.But just minutes later, The Titans cut the deficit to one touchdown through the handy work of Clancy who crossed in the right corner.However, the Cowboys continued to pile on the pressure and it paid off in the 16th minute, with Cormac Hoch scoring a spectacular touchdown to put his side up 3-1. That’s the way it stayed at half-time, and the Cowboys used that momentum to go on with the match and claim the title.Queensland Cowboys 6 (C. Hoch 2, L Hoch, Hegarty, Hughes, Moore touchdowns) def. Queensland Titans 3 (Clancy 3 touchdowns)Related LinksMen’s E8 final
Junior center Amir Williams (23) dunks the ball during a game against Iowa Feb. 4 at Carver-Hawkeye Arena. OSU won, 76-69.Courtesty of The Daily Iowan/Alyssa HitchcockWhen a team is on the road in a hostile environment, college basketball coaches typically look to their seniors to lead the way.That was the case Tuesday night in Iowa City, Iowa, as Ohio State senior guard Aaron Craft did a little bit of everything to help lead his team to its second straight road win, defeating No. 17 Iowa, 76-69.Craft finished with a game-high 17 points, recorded six steals, dished out six assists and delivered a crucial driving layup with 1:21 remaining while getting fouled. His free throw put the Buckeyes (18-5, 5-5) up, 66-59, but Iowa would not go away.The Hawkeyes (17-6, 6-4) cut the lead to four after a free throw by senior forward Zach McCabe with 54 seconds left, but they never got that close again.The battery of junior guard Shannon Scott, junior forwards LaQuinton Ross and Sam Thompson and senior guard Lenzelle Smith Jr. combined to make 10 of 12 free throws after the lead was cut to four to help seal the win for the Buckeyes, who won their second straight game against a top 20 opponent — following up a 59-58 victory at then-No. 14 Wisconsin in Madison, Wis.The Buckeyes shot 25-49 from the field in the game, including 7-16 from beyond the arc. Their perimeter defense proved to be the difference, as Iowa shot just 3-20 from deep.After trailing, 33-31, at halftime, OSU took the lead for good after Smith Jr. buried a three from the wing with 18:39 remaining. Smith Jr. finished with 12 points, one of five OSU guys to score in double figures including Craft, Ross with 13, junior center Amir Williams with 12 and Scott with 11.Sophomore guard Mike Gesell led the Hawkeyes with 16 points, and junior center Gabriel Olaseni added 14 off the bench.After the two straight road wins, OSU is set to come home Saturday and take on Purdue (13-9, 3-6). The Buckeyes last beat the Boilermakers, 78-69, Dec. 31 in West Lafayette, Ind. Tipoff for Saturday is set for 6 p.m.
Hachette Filipacchi Media U.S. has partnered with Theorem Inc. to use the custom operations company’s Analytics 2.0 program—an automated system that manages display ad inventory, traffic and performance across the publisher’s portfolio of Web sites. Analytics 2.0 allows magazines to upload data in multiple forms and generate reports by using customizable templates and formulas. “The program enables publishers and magazines, specifically companies that are migrating content on the Web, to bring together their ad serving reports and site analytics data in one central interface,” Theorem founder and CEO Jay Kulkarni told FOLIO:. “This allows ad operations, sales and finance to look at their reports in a comprehensive way.”The program is equipped with built-in tools that accommodate data from ad servers, search engines, site side data and rich media, and can handle terabytes of data produced by online marketing campaigns. There is no software to be installed, Kulkarni says, and reports can be generated in HTML, Adobe, Excel and other Microsoft formats. Set-up time takes a couple of weeks to go into live production.“We manage 12 Web sites that run thousands of campaigns, and had people in-house crunching numbers in Excel manually,” said Oleg Korenfeld, Hachette’s director of advertising operations. Hachette has been using Analytics 2.0 since January. “We needed better CPM, better sell-through, not only historically but also using forecast tools. This program makes everything automated, generating weekly reports. “The service saves us a lot of time and money,” Korenfeld added. “It’s not expensive. It costs a lot less than having someone in-house build a similar program, and frees up our current staff to focus on other projects.”A typical contract costs between $2,000 and $8,500 per month depending on data sets, frequency or reports and the amount of customization, Kulkarni says. “Our clients use the program to manage their online operations in a holistic fashion, look at ways to drive revenue by looking at campaign performance and provide trends to their advertisers. For one magazine client, what took four weeks to generate a report was reduced to only two days.”In addition to Hachette, Theorem is working with three other magazine clients, according to Kulkarni.
The House adopted the fiscal 2016 conference budget resolution last Thursday, a compromise that strips out a procedural hurdle that could have blocked the Senate from allocating tens of billions of extra dollars included in DOD’s war account.To evade the $523 billion Budget Control Act cap on national security spending, the budget blueprints advanced in both the House and Senate allot $96 billion — including $58 billion requested by the Obama administration and $38 billion in extra funds — to the department’s overseas contingency operations account (OCO). That account is not subject to the budget caps.The Senate version, however, included a point of order on spending from the OCO exceeding $58 billion, a mechanism that likely would have required defense hawks to produce 60 votes to override any objections raised by Senate Democrats or fiscal conservatives. The maneuver essentially would have counteracted the chamber’s attempt to sidestep the budget caps by stashing extra funds for DOD in the OCO.House and Senate conferees removed the Senate point of order due to pressure from defense hawks, reported CQ Roll Call. The Senate is expected to take up the conference report, which will not go to the president for his signature, as early as today.While the compromise budget resolution removes any obstacles to appropriators allocating the extra defense funds, it will not become law and, as a result, does not settle the dispute between congressional Republicans and the White House over how to deal with the statutory spending caps. President Obama has vowed to veto any FY 2016 spending bills that adhere to the Budget Control Act caps or provide budgetary relief only to the Pentagon. Absent a bipartisan agreement to lift the caps for both defense and non-defense agencies, it is not clear how the government will be funded next year. Dan Cohen AUTHOR
gunfightAn accused of a rape incident was killed in a reported gunfight with police in Hijaldi village of Kalaroa upazila in Satkhira early Sunday, reports UNB.The deceased is Sohag Dalal of Boalia village and the lone accused of the rape case, filed on Saturday, in connection of raping a class III student.Being tipped off a team of police in a drive arrested Sohag around 2:00am, said Biplab Nath, officer-in-charge of Kolaroa Police Station.Sensing the presence of the law enforcers, Sohag and his associates hurled brick chips and bombs towards police, prompting them to retaliate, triggering the gun battle, leaving Sohag injured, said the OC.Later, he was rushed to Kolaroa Upazila Health Complex where doctors declared him dead. Two assistant sub-inspectors were also injured during the ‘gunfight’.Police also recovered one shooter gun and five round bullets from the spot.The law enforcement’s version of the event was, however, not verified independently as no version of the incident was available immediately either from any witnesses or from any members of the victim’s family.
Share CHI St. Luke’s HealthThe Baylor-St. Luke’s hospital in the Texas Medical Center is getting a new president. Gay Nord returns to her hometown of Houston from San Antonio, where she was president and CEO of Methodist Hospital.Baylor-St. Luke’s is part of a nonprofit chain of hospitals known as Catholic Health Initiatives. The hospital is currently housed in the old St. Luke’s tower in the Medical Center, but will eventually move to a new campus off Old Spanish Trail. That campus is currently under construction and will be finished in 2019. It will house the 650-bed hospital, doctor’s offices, research space, and the Texas Heart Institute.While at Methodist in San Antonio, Nord expanded the types of cardiac services offered at the hospital, adding a Cardio-Oncology program to help mitigate the damage that cancer treatments can have on the heart. She also added an Adult Congenital Heart Program and a Structural Heart Program.Before San Antonio, Nord worked for three hospitals that are owned by HCA, a for-profit hospital chain. Two of those were in Houston: Kingwood Medical Center and West Houston Medical Center.Nord received her undergraduate degree in business from the University of Houston, and a master’s in Health Care Administration from Texas Women’s University.
THE LATEST on a small airplane that went missing over the Gulf of Mexico (all times local):– / 312:35 p.m.A dog rescue group says the pilot of a small plane that disappeared over the Gulf of Mexico was flying to Central Texas to collect a disabled dog and deliver it to a foster home in Oklahoma.Coast Guard spokeswoman Lexie Preston on Thursday identified the pilot as Dr. Bill Kinsinger.The executive director of the Oklahoma Medical Board, Lyle Kelsey, says Kinsinger serves on the board and lives in Edmond, Oklahoma. Kinsinger is an anesthesiologist.Monica Marshall coordinates flights for the nonprofit group Pilots N Paws and says she was tracking Kinsinger’s plane Wednesday when radar showed it veered off course by hundreds of miles.Marshall says she has been unable to reach him by text and phone.She says Kinsinger didn’t collect the disabled dog in suburban Austin, Texas.___10:05 a.m.Officials say the pilot of a small plane that stopped responding to air traffic controllers and disappeared over the Gulf of Mexico was unresponsive and may have been suffering from a lack of oxygen.The plane took off from Oklahoma City on Wednesday afternoon and was supposed to land in Georgetown, Texas, but kept going. A spokesman for the North American Aerospace Defense Command, or NORAD, says two F-16 fighters were launched from a base in Houston to make contact with the plane Wednesday.NORAD says the fighters flew in front of the plane, dropped flares and performed other military maneuvers in an effort to gain the pilot’s attention, but the pilot appeared to be unresponsive. NORAD says the pilot was the only person on board the plane.The Eighth Coast Guard District, referencing the NORAD report, says the pilot appeared to be suffering from hypoxia, in which the brain is deprived of adequate oxygen. The condition can cause confusion, nausea, breathlessness and hallucinations.The search for the aircraft is ongoing in the Gulf of Mexico.___7 a.m.The U.S. Coast Guard is searching the Gulf of Mexico for a small plane that didn’t land at its scheduled location in Central Texas and stopped responding to air traffic controllers.The Cirrus SR-22 took off Wednesday afternoon from a small airport in Oklahoma City after filing a flight plan to land in Georgetown, Texas, about 25 miles (40 kilometers) north of Austin.Federal Aviation Administration spokesman Lynn Lunsford says the plane kept flying and was last observed on radar 219 miles (352 kilometers) northwest of Cancun flying at 15,000 feet (4,600 meters).The plane is registered to Oklahoma-based Abide Aviation. Share
Explore further Phase folded curve of the planetary signal detected in GJ 625 using the parameters of the MCMC model. Left panel shows the CCF measurements, right panel the TERRA measurements. Grey dots show the measurements after subtracting the detected activity induced signals. Red dots are the same points binned in phase with a bin size of 0.1. The error bar of a given bin is estimated using the weighted standard deviation of binned measurements divided by the square root of the number of measurements included in this bin. Blue line shows the best fit to the data using a Keplerian model. Credit: Mascareño et al., 2017. Scientists discover a nearby superearth This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. “Super-Earths” are planets more massive than Earth but not exceeding the mass of Neptune. Although the term “super-Earth” refers only to the mass of the planet, it is also used by astronomers to describe planets bigger than Earth but smaller than the so-called “mini-Neptunes” (with a radius between two to four Earth-radii).Located only 21 light years away, GJ 625 is an M-dwarf star (spectral type M2) about 1/3 the size and mass of the sun. Such stars offer great potential in the search for alien Earth-like worlds, as low-mass rocky planets appear to be more frequent around M-dwarfs. However, finding an Earth-like planet orbiting low-mass stars is difficult due to their stellar activity. This is because signals induced by the rotation of a star can easily mimic those of planetary origin. Therefore, the signals coming from M-dwarfs tend to be comparable to those of rocky planets close to the habitable zone of their stars.Recently, a team of astronomers led by Alejandro Suarez Mascareño of the Canary Islands Institute of Astrophysics, has completed challenging studies of GJ 625, which began in 2013 and lasted over three and a half years. The observations were conducted with the High Accuracy Radial velocity Planet Searcher for the Northern hemisphere (HARPS-N) spectrograph installed at the Telescopio Nazionale Galileo at the Roque de los Muchachos Observatory on the island of La Palma, Canary Islands, Spain.The researchers analyzed 151 radial-velocity time series from HARPS-N as part of the HArps-n red Dwarf Exoplanet Survey (HADES) radial velocity program, which resulted in the discovery of a new planet.”We report the discovery of a super-Earth orbiting at the inner edge of the habitable zone of the star GJ 625 based on the analysis of the radial-velocity (RV) time series from the HARPS-N spectrograph, consisting in 151 HARPS-N measurements taken over 3.5 yr,” the paper reads.The newly found alien world, designated GJ 625 b, has a minimum mass of 2.8 Earth masses, which makes it the lightest exoplanet found around an M2 star to date. The planet orbits its host every 14.6 days at a distance of approximately 0.08 AU from the star, which is relatively close. By comparison, Mercury orbits the sun at a mean distance of 0.38 AU. The results of radial velocity measurements allowed the team to conclude that GJ 625 b is a small “super-Earth” on the inner edge of the habitable zone and has a mean surface temperature of 350 K that is very dependent on the atmospheric parameters. Moreover, the researchers assume that the newly detected exoworld might potentially host liquid water, but more observations focused on GJ 625 b’s atmosphere are required to confirm this assumption. (Phys.org)—European astronomers report the detection of a new extrasolar world several times more massive than Earth. The newly found exoplanet, classified as a so-called “super-Earth,” is circling a nearby star designated GJ 625. The researchers detailed their finding in a paper published May 18 on arXiv.org. Citation: Astronomers discover ‘super-Earth’ planet orbiting nearby star (2017, May 29) retrieved 18 August 2019 from https://phys.org/news/2017-05-astronomers-super-earth-planet-orbiting-nearby.html More information: HADES RV Programme with HARPS-N at TNG: V. A super-Earth on the inner edge of the habitable zone of the nearby M-dwarf GJ 625, arXiv:1705.06537 [astro-ph.EP] arxiv.org/abs/1705.06537AbstractWe report the discovery of a super-Earth orbiting at the inner edge of the habitable zone of the star GJ 625 based on the analysis of the radial-velocity (RV) time series from the HARPS-N spectrograph, consisting in 151 HARPS-N measurements taken over 3.5 yr. GJ 625 b is a planet with a minimum mass M sin i of 2.82 ± 0.51 M⊕ with an orbital period of 14.628 ± 0.013 days at a distance of 0.078 AU of its parent star. The host star is the quiet M2 V star GJ 625, located at 6.5 pc from the Sun. We find the presence of a second radial velocity signal in the range 74-85 days that we relate to stellar rotation after analysing the time series of Ca II H&K and Hα spectroscopic indicators, the variations of the FWHM of the CCF and and the APT2 photometric light curves. We find no evidence linking the short period radial velocity signal to any activity proxy. © 2017 Phys.org
Kolkata: In a bid to avert any incident of fire, the state government is taking all necessary moves to ensure a “hogla pata free” Gangasagar Mela in 2019.Gangasagar Mela in Sagar Island takes place in January every year, in which lakhs of pilgrims from all over the country turn up to take holy dip at the confluence of river Ganga.The state government initiates the necessary planning from September onwards to ensure a safe and secure Gangasagar Mela and a meeting with the Chief Secretary was already held in Nabanna in the last week. Also Read – Rain batters Kolkata, cripples normal lifeSources said that following direction of Chief Minister Mamata Banerjee, initiatives have been taken to make the mela “hogla pata free”. Usually, hogla leaves are used in making makeshift accommodation facilities for people who visit the place during the mela.More than 1,000 huts are required to be set up every year for accommodation of the people. But it has been pointed out that the hogla leaves highly inflammable. There was also an incident of a small fire at the Gangasagar Mela in 2017. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedThe matter came up in the meeting that was held in Nabanna last week and the concerned authorities have started carrying out the necessary work to find out an alternate material, using which the huts can be made.”Engineers of the Public Health Engineering (PHE) department, the modal department to organise the mela, are carrying out a study to finalise the material that can be used to construct the makeshift huts,” said a senior state government official, adding that it was initially thought that corrugated tin can be used to build the huts. “But it would not be that safe as it is a good conductor of electricity. Since many wires need to be laid to transmit power to the makeshift structures, using corrugated tin would not be a good option,” the official said. He further added that the PHE engineers are trying to find out a fire retardant material that can be used to construct the huts.Makeshift accommodation facilities are set up for senior administrative and police officers, media persons, volunteers and pilgrims. Hogla leaf huts lined up one after the other had been a common feature of the mela for ages. Now, with the initiative taken by the state government, it would be a safer and more secure mela for the pilgrims.
Chimu Adventures director Greg Carter, McGrath Foundation ambassador and director Tracy Bevan and Artist Ken Done Chimu Adventures and the McGrath Foundation, along with Australian artist Ken Done, showcased the up and coming feature voyage to Antarctica named ‘PinKtarctica’.The ‘PinKtarctica’ voyage will take place over 12 days, allowing travellers to explore the Antarctic Peninsula, whilst supporting the McGrath Foundation’s mission to raise money to fund McGrath Breast Care Nurses in communities across Australia and increasing breast awareness in young Australians.Travellers aboard the expedition will be joined by McGrath Foundation ambassador and director Tracy Bevan and Ken Done.McGrath Foundation ambassador and director, Ms Bevan, said the fundraiser will go a long way in helping the Foundation ensure every family in Australia experiencing breast cancer has access to a breast care nurse no matter where they live or their financial circumstance.“We are proud to have funded 100 McGrath Breast Care Nurses working nationally, who together have supported over 25,000 families experiencing breast cancer in Australia and remarkable events like PinKtarctica will truly help us to continue to make a difference,” Ms Bevan said.Source = ETB Travel News: Megan Tran
Reps. Marino, Yaroch: Bucci should resign or be removed from officeState Reps. Steve Marino and Jeff Yaroch today sent Gov. Rick Snyder letters calling on him to exercise his authority to remove a Macomb Township trustee from office.Rep. Marino said Trustee Dino Bucci has exhibited corrupt conduct in office and gross neglect of duty, both of which the governor can use as grounds for his removal under the Michigan Constitution.“Dino Bucci’s actions while serving as both a township trustee and public servant in the Macomb County Department of Public Works are disgraceful and unacceptable,” Marino said. “Even more shameful is the fact that he continues to receive cadillac health benefits, collect a salary, and hold his title while skipping meetings and avoiding all other official responsibilities.”Rep. Yaroch said: “Public Works Commissioner Candice Miller has relieved Mr. Bucci of his duties at the Macomb County Works office, which is rebuilding the trust of Macomb County in that department. It is time for Gov. Snyder to do the same to rebuild the trust of our citizens in their government.”Bucci was indicted by a federal grand jury in November 2017 on eighteen counts of conspiracy, bribery, embezzlement, extortion, mail fraud and money laundering. The charges are in connection with public contracts in Macomb Township and the Macomb County Department of Public Works, where he worked until 2017.“Trustee Bucci has clearly lost the trust and confidence of both his colleagues and the public,” Marino said. “If he won’t resign, it’s time for Gov. Snyder to exercise the authority granted to him by the state constitution and allow our community to begin the healing process.”The legislators, who each represent a portion of Macomb Township in the Michigan House, also sent letters to the Attorney General’s Office requesting a formal opinion clarifying the governor’s authority to remove Bucci from office.### 18Apr State representatives call on governor to remove Macomb Township trustee Categories: Yaroch News
Ten properties were searched in Derry while two addresses were raided by Gardai in Donegal.£1M DIRTY ASSETS PROBE: FOURTH PERSON REMANDED TO DERRY COURT was last modified: June 22nd, 2017 by John2John2 Tags: ShareTweet The 36-year-old was charged with conspiracy to supply a Class B drug, entering an arrangement to acquire criminal property, converting criminal property, and possession of a Class B drug.Fox was released on bail to appear at Derry Magistrates’ Court on Monday, July 3.A fifth person arrested in connection with the operation is due to appear at Belfast Magistrates’ Court next month.A total of 20 addresses were raided by detectives from the PSNI’s Reactive and Organised Crime Branch as part of the investigation. BARRY FOXCO TYRONEdungannonDUNRAVEN COURTPSNISTRABANE MAGISTRATES’ COURT£1M DIRTY ASSETS PROBE: FOURTH PERSON REMANDED TO DERRY COURT A father of two has face a court as part of a PSNI investigation into a dirty cash racket, drug dealing and property racket with assets totalling £1 million.He was the fourth person to appear in court today for a first remand hearing as part of the year long cross border police probe.Appearing in the dock of Strabane Magistrates’ Court was Barry Fox from Dunavon Park in Dungannon, Co Tyrone.
Keen eye for good stories and big ideas Recommended Link Kansas farm boy generates millions from his California “bunker” He’s just an ordinary guy born on a farm in Kansas. He didn’t graduate from a fancy college. He doesn’t have an MBA. Yet he stumbled upon a “secret key” technique that allowed him to retire at 42… and still make more money in 8 hours… than most people make in a month. But Monday through Friday you’ll find him up by 4 am, in front of his computer… using his “secret key” to generate thousands of dollars per week… without touching stocks or bonds. He calls it his retirement hobby. Click here to see it in action. The Job We Need DoneWe’re looking for someone who loves investment analysis. Someone who wants to make a living reading, thinking, traveling, and writing. Someone who can help us share big ideas with the world.If this sounds attractive—and you meet the criteria above—we’d love to hear from you.The compensation will depend on your level of experience. Know this: Dozens of analysts at Agora (our parent company) who write newsletters have become millionaires.What to Do Now Send us a basic resume. We’d like to see where you’ve worked.Write a letter telling us about yourself. We don’t care much about what school you went to. We do care about what you’ve learned doing whatever it is you’ve been doing. We appreciate odd jobs, but we’re also willing to consider Wall Street refugees.Send us an email with the following information… Independent thinker who is passionate, motivated, and eager to overachieve Trustless SystemThe decentralized revolution is about getting rid of “trusted” third parties. Ultimately, coins like Tether will fail if they can’t find a way to become “trustless.”(With trustless technology, you don’t have to know or trust the person you’re doing business with. The blockchain records and verifies every transaction transparently. So the system builds trust by default.)Back to the University of Texas report… It suggests that more Tethers were issued than had backing by actual dollars. The report makes the case that Tethers were used to prop up—and ultimately manipulate—the price of bitcoin.Kessler’s article attempts to use the study to bolster his argument that bitcoin is just another balance sheet-driven bubble, just like every bubble since the South Sea Bubble of 1720.He argues that temporarily shifting assets from one balance sheet to another inflates a bubble. When the money runs out, the bubble pops.It’s the type of argument that initially reads well… But it doesn’t really hold up under scrutiny.For instance, Kessler tries to pin the dot-com crash on America Online’s dot-com-era ad policies. I read his explanation three times, and I still don’t understand how AOL’s ad policies could have caused the dot-com crash.The dot-com boom was a $5 trillion bubble. It seems a bit of a stretch to pin $5 trillion worth of value destruction on one company’s ad policies.Kessler also blames the infamous Dutch Tulip Mania of 1636–1637 on balance-sheet manipulation. But that doesn’t work, either. If he had really done his research, he would have found out that the Tulip Mania was an overblown myth. It had nothing to do with balance-sheet manipulation.(The Smithsonian journal did a great write-up on the Great Tulip Mania and called it more of a fanciful fiction than a serious financial crisis. You can read the essay here.) Teeka Tiwari Editor, Palm Beach ConfidentialP.S. For the first time ever, I have an investment announcement so BIG that I’ve teamed up with media personality Glenn Beck to create a one-off, special event. We’re calling it The Great Cryptocurrency Conspiracy of 2018. It will broadcast online on July 19, live from Glenn’s Dallas studios.When you register for the July 19 event, you’ll get a free copy of my new report, The Crypto Manifesto: Why Cryptocurrencies Are the Smartest Speculation You Can Make Today.Plus, you’ll have the chance to claim your portion of free bitcoin during the first $2 Million Bitcoin Giveaway.You can reserve your seat for this free event, plus get a free copy of my report, by registering right here…Reader MailbagToday, a reader responds to Thursday’s Dispatch—“How to Profit From the Biggest Oil Shock Ever”—where we interviewed Crisis Investing editor Nick Giambruno on why a potential conflict in the Middle East could trigger the next huge oil shock…The oil prices went up because Richard Nixon was colluding with the Saudis to figure out a way for the Saudis to afford US warplanes because Vietnam was winding down and the American war-mongering billionaires needed to make more billions off the backs of US citizens! —RichardAnd another reader shares his thoughts on our recent interview with Doug Casey on California breaking apart…Well, politics is violence, so this separation of “Corruptifornia” into three states is bit like treating the symptom and not the “disease.” Living in the Fresno area, aside from demographics that are dominantly Hispanic, I don’t see much in common with San Diego, Riverside, and the rest of those included in one of those proposed “states.” I don’t believe “statism” is moral. I believe it is just constitutionalism, and both are wickedness.—JackAs always, if you have any questions or suggestions for the Dispatch, send them to us right here. Volatile AssetIf Kessler is going to attack the 2017 action as being manipulated, why not attack the 2011, 2013, and 2014 “bubbles”?Were all of those moves manipulated, too?If they were, then those are the most unique bubble manipulations I’ve ever seen.Here’s what I mean…If you bought at the peak of each move, your average “old” peak to “new” peak gain would be 9.8 times your money.How many bubbles do you know of that could make you money if you bought at the peak of every move?I don’t know of any others.I fear Kessler has confused market volatility with market bubbles. Just because something is volatile doesn’t automatically make it a bubble (or mean that it’s been manipulated). Bitcoin is volatile… but it’s also very valuable.Fraudulent assets go to zero. True bubbles don’t continue to make higher highs and higher lows the way bitcoin has done.Bitcoin is a highly volatile asset—not a fraudulent asset.And that’s why I have always recommended that my readers keep their position sizes small.(In Palm Beach Confidential, we recommend that investors with smaller accounts place no more than $200–$400 per trade… and that investors with larger accounts place no more than $500–$1,000 per trade.Cryptocurrencies are volatile. So small position sizes will allow you to keep a cool head during extreme periods of volatility, like we’re seeing in the current crypto market.)It’s the only prudent way to invest in assets like bitcoin and other cryptocurrencies.But let’s get back to Kessler’s central theme on manipulation…Has the issuance of unbacked Tethers manipulated the market higher? It’s possible. I don’t know if we’ll ever really know for sure.But in the long run, does it really matter? I don’t think it does.The truth is that sometimes, bad people co-opt great companies and great technology.Speculators used to manipulate early railway stocks all the time. In the early days of General Motors, founder Billy Durant routinely manipulated company stock.These short-term blemishes did nothing to diminish the long-term value the rail and automotive industries were ultimately creating.Meanwhile, amid all the manipulation hubbub, we continue to see signs of the mainstream adoption of bitcoin and other cryptocurrencies. If we poke a little more, we can find more holes in Kessler’s bubble theory.If Kessler is right about last year’s crypto market action, how does he explain the so-called bitcoin bubbles of 2011, 2013, and 2014?That’s right, this is the fourth time bitcoin’s “bubble” has popped… — The net gain on 10 shares of McDonald’s stock purchased January 3, 2007 and sold January 3, 2017, assuming all dividends were reinvested. Recommended Link Wanted: Expert Investment AnalystHey, we’re looking to hire an analyst for the Casey Research team. Our team is growing and a new spot has opened up for an ambitious person to research and write about commodities, stocks, crypto assets, and world markets.For this position, you’ll work directly with Nick Giambruno, Chief Analyst for and editor of The Casey Report and Crisis Investing. Nick is Doug Casey’s globetrotting protégé. He writes about geopolitics, value investing in crisis markets, the cannabis market, global banking, and survival techniques for financial crises.If this sounds stimulating, keep reading for more details and how to apply.Who We AreWe’re a fast-growing company with all the opportunities of a small start-up and the stability of a deep-pocketed firm with a 30-year track record.We publish half a dozen advisories covering finance and economics. We have hundreds of thousands of readers around the world. Our business is in providing profitable ideas, explaining how the markets really work, and telling great stories.We’re completely independent and unbiased. We don’t take money from Wall Street or the government. Our revenue comes from selling subscriptions. We make money only if our readers are happy.Who You AreYou’re able to analyze assets from macro, technical, fundamental, and sentiment perspectives. You’re overflowing with investment and trading ideas. And you’re a voracious consumer of information.You have a genuine passion for finance and the investment industry. You’re intensely curious, and live and breathe the world’s markets. And you’re willing to travel anywhere and everywhere. You’re ready to improvise, adapt, and overcome.You’re a good thinker, storyteller, and writer. You’re also good company, and you’re the one your friends say is the smartest person in the room.“Must-haves”: The St. Louis Fed recently announced it has created an index to track the top four cryptocurrencies. 2018 bubble “pops”: $20,000 to $6,500—down 66% so far… Goldman Sachs announced plans to start a bitcoin trading desk. 2011 bubble “pops”: $32 to $2—down 94% Your full name. And there’s more…By 2002, the dot-com crash caused the Nasdaq to drop 80%. In 2002, venture capital (VC) investment dropped by 90%.Contrast that with cryptos.Right now, the crypto market is down around 67% from its high. It seems logical that funding for new VC deals would dry up. But it hasn’t.VC investment has already doubled from last year, and it’s expected to quadruple by year end.The key takeaway is that even with the news of manipulations, government meddling, and massive volatility… institutional money is still flowing into this asset in droves.And what an institution chooses to do with its money will always carry more weight with me than a Wall Street Journal op-ed piece.Let the Game Come to You! Personal philosophy of voluntarism, anarcho-capitalism, or something similar Current Casey Research subscriber (paid memberships to Crisis Investing or The Casey Report win extra points) Weird new “antennas” popping up all over America NASDAQ calls it: “The biggest investment opportunity in years.” These antennas have nothing to do with your cell phone, hiding inside is the biggest hi-tech secret of the decade. Click here to learn more. — 2013 bubble “pops”: $230 to $70—down 70% Exceptional writing ability or a willingness to learn how to write Justin’s note: Today, I’m handing the reins to world-renowned cryptocurrency expert Teeka Tiwari, who has an important update on the crypto space.Below, Teeka responds to a recent piece in The Wall Street Journal that claims bitcoin’s spectacular price run in 2017 was partly due to market manipulation. But Teeka says the author’s missing a major detail… By Teeka Tiwari, editor, Palm Beach ConfidentialAt first blush, Wall Street Journal technology writer Andy Kessler makes a compelling case for why bitcoin’s 2017 meteoric 1,368% rise was not “real.”In an article published on Sunday, July 1, Kessler cites a University of Texas study that argues manipulation was behind half of bitcoin’s 2017 move upwards. The study pins the blame on a crypto coin called Tether (USDT).Tether is a fixed-value, or “stable” coin. It supposedly backs each coin with one U.S. dollar. To be clear, I have never been a fan of Tether because it requires you to trust that there is $1 backing each coin.In the January 2018 issue of my Palm Beach Confidential newsletter, I wrote:[Tether] claims that for every Tether in the market, it has an actual dollar bill in a vault somewhere.Let me be clear: I HAVE NEVER BELIEVED THAT CLAIM. That’s why I never recommended the token.To date, I still haven’t seen proof of Tether’s reserves.Many people share my misgivings about Tether… But that hasn’t stopped it from issuing more than $2.5 billion worth of coins. Does Tether have $2.5 billion in cash reserves to back that up? Or is it just printing its own money at will?Nobody knows. Can governments shut down bitcoin? Explain why or why not. The cause of the Great Depression in the U.S. and why. Japan’s Nomura Holdings (a $100 billion-plus financial firm) just announced it’s creating a crypto custody consortium (an institution that holds securities or assets for safekeeping) called Komainu. The top three biggest risks to the global economy and why. 2014 bubble “pops”: $1,200 to $173—down 85% Why has the average person’s standard of living declined since the early 1970s? Affinity for Austrian economics, monetary history, financial markets, and general history Prepare for conversation and travel. If you have what we’re looking for, you’ll start out with a one-on-one conversation with Nick. If that goes well, we’ll fly you to Delray Beach for a full day of interviews. And if we still like each other after that, we’ll discuss the next steps.Get in touch at email@example.com. Put “Investment Analyst” in the subject line. That’s your first test. In Case You Missed It…The economy is growing, and stocks remain near all-time highs. But behind the scenes, something strange is happening…The US government and global financial elites are considering implementing a radical new change to America’s money. If passed, the money in your bank account would fall firmly under government control.They call it “The Chicago Plan.”
Want to know what the teenagers in your life really think about sex and drugs?Are you sure?Well, researchers at the Centers for Disease Control and Prevention have a pretty good idea, thanks to the Youth Risk Behavior Survey. Every other year, thousands of teens in public and private high schools across the country take this nationally representative survey. The CDC just released results for 2017, and here are a few of the highlights:SexTeens’ experiences with sex are changing, and the news is almost all good, says Kathleen Ethier, director of CDC’s Division of Adolescent and School Health.”Fewer are initiating sex,” Ethier says, “fewer are currently sexually active, they’re having fewer partners, and they’re using more effective hormonal birth control methods.”In 2007, nearly 48 percent of teens said they’d had sex at least once. A decade later, it’s 39.5 percent. One change in the data that Ethier’s not happy about is a recent decline in condom use.In 2007, 61.5 percent of teens said they’d used a condom during their last sexual encounter. By last year, that rate had dropped to 53.8 percent. Ethier says this is due, at least in part, to “a decrease over time in requirements that school cover HIV and [sexually transmitted diseases] in health education programs.”According to the report, young people aged 15-24 account for half of the roughly 20 million new STDs reported each year.One more red flag, Ethier says: More than one in 10 young women (11.3 percent) reported being forced to have sex.DrugsWhen it comes to illicit drugs — like cocaine and heroin — teen use is way down, from 22.6 percent in 2007 to 14 percent in 2017.For the first time, though, the survey also asked teens if they have ever misused prescription opioids. Fourteen percent said they had.”We don’t know what this 14 percent number means, but we were quite surprised by it,” Ethier says, adding that CDC has more work to do to understand what these new data say about the opioid crisis and teens’ role in it.ViolenceThe survey also asked high-schoolers about bullying and violence at school. One in 5 said they’d been bullied at school. Fifteen percent said they’d been bullied electronically.The rate of students who said they’d been threatened or injured with a weapon at school has dropped significantly in the past decade. But students of color are still far more likely than white students to say they missed school because of safety concerns at school or in their communities.Mental HealthPerhaps the biggest red flags were in the section devoted to mental health.Roughly a third of teens surveyed said they’d experienced persistent feelings of sadness or hopelessness.”I think that’s really significant,” says CDC’s Ethier, “and certainly not what we want to see if we’re trying to send our kids into adulthood in the most healthy way.”The news is even worse for students who identify as lesbian, gay or bisexual.Nearly two-thirds reported persistent feelings of sadness or hopelessness.In fact, in every category, LGB teens were at higher risk than their heterosexual classmates. They were twice as likely to report being bullied in school or electronically, three times as likely to seriously consider suicide and four times as likely to attempt suicide.”It’s shocking and alarming and tells us that things are terribly wrong,” says Ellen Kahn, director of the Children, Youth & Families program at the Human Rights Campaign Foundation. “We seriously need to address this.”Kahn says these data are a stark reminder of the lack of protections at the federal, state, district and school level for LGB teens and of why, she says, these protections are so sorely needed. Copyright 2018 NPR. To see more, visit http://www.npr.org/.
Government plans for a huge expansion of personal health budgets could help to deliver independent living for disabled people, according to a leading disabled peer.Baroness [Jane] Campbell (pictured), who has been receiving a personal health budget herself for more than a year, said the plans also had “huge potential” for “getting to grips” with the integration of health and social care support.But the government’s plans faced determined opposition from other disabled campaigners this week, with many concerned that they could be part of a planned creeping privatisation of the NHS.They were speaking after the government launched a consultation on the plans to expand the legal right for people to have choice and control over their healthcare through personal health budgets (PHBs).One mental health activist said the plans were about “offloading us to the private sector”, and said she feared that funds would only be made available “as a temporary sweetener” until privatisation of the NHS was complete, when they would be withdrawn.PHBs give individuals a pot of money to spend on their health and wellbeing needs, in agreement with a healthcare professional.Some areas of NHS care will not be covered by a PHB, including GP services, unplanned hospital admissions, drugs and operations. Currently, only about 23,000 people receive a PHB, but reports suggest that ministers want to increase this to about 350,000.The Department of Health and Social Care (DHSC) says the plans would allow individuals “to control and tailor their own health and care, based on their own individual needs, in a manner that abides by the constitutional values of healthcare being free at the point of delivery, based on clinical need, not on ability to pay”.The consultation stresses that PHBs would remain optional.The government is suggesting expansion could focus on five groups who have an ongoing need for NHS services: those with continuing social care needs; those with ongoing mental health needs; people leaving the armed services; people who are autistic or have learning difficulties; and people who access NHS wheelchair services.At present, only those in receipt of NHS continuing healthcare – and children and young people receiving continuing care – have a legal right to a PHB.But the government also wants to give more people the right to combine their PHBs and social care personal budgets into a single integrated budget – so they will only need a single assessment of all their needs – and potentially add other funding streams, such as disabled facilities grants.It also proposes giving some service-users the right to receive their PHB through direct payments, which would enable them to take a cash payment to manage and pay for their own support.But many disabled activists fear the plans are only the next step in a move towards privatising the NHS.Professor Peter Beresford, co-chair of Shaping Our Lives, said: “Everyone who loves the NHS should fear the government’s determination to extend personal health budgets massively.”He said PHBs were “the antithesis of the NHS founding principles of universality and needs-led provision”, particularly as the government had based PHBs on the same “failing” model used with social care personal budgets.Under personal budgets, service-users are given an upfront allocation of funding, but that often bears no correlation to what is actually available for the service-user to spend on their support.Beresford believes the same will happen with PHBs.And he warned that “further encroachment of the NHS into social care is no way to bring about integration of health and social care.“The great bulk of spending through PHBs is on social care – PAs, home care, respite, leisure and social needs – with a smattering of spending on fringe or complementary health services that the mainstream NHS will not commission.“In effect, as a strategy to bring about integration, it will fail as it doesn’t grapple with the real problems of integrating clinical health and social care.”He said PHBs were also “morally highly questionable” because they will extend the “anomaly” with NHS Continuing Healthcare, where “some will get free social care via PHBs and the rest will have to pay for exactly the same service”.He said: “PHBs aren’t a gift horse; they are a Trojan horse for privatisation and the commodification of health.”Denise McKenna, co-founder of the Mental Health Resistance Network, said she also feared the plans were part of a long-term government strategy to privatise the NHS and move to an insurance-based system similar to the one that operates in the US.PHBs, she said, would allow the government to separate those service-users who would be “uninsurable” and unprofitable under an insurance-based system, including those with severe and enduring mental health conditions.She said: “I understand people with physical disabilities find PHBs excellent and it is really important to independent living that people are in control of their own lives.“My fear is not in the here and now. It is what is going to happen in the future, what their motives are and what it will lead to.“My fear is that it is a major step towards privatisation.”McKenna said her own experience was that it was “practically impossible” for people with mental health conditions to secure a social care personal budget.For those who were able to, she said, they were unable to benefit from the funding because the scheme was so badly run.Clenton Farquharson, chair of Think Local Act Personal – a national partnership committed to health and care personalisation and community-based support – and a consultant on equality and inclusion, welcomed the government’s plans.He said: “We know from our experience of personal budgets that when implemented well they enable choice, control and improve wellbeing.”He said he was not concerned by claims that the government’s plans were part of creeping privatisation of the NHS.He said: “Personal health budgets are motivated by an underlying principle to humanise a bureaucratic approach to supporting people with long term health and social care support.“They are also driven by a need to effectively integrate health and social care that will help minimise costly, confusing and unsustainable processes that, in my experience, has had a negative impact on my life. “I am not aware of any evidence that suggests the further expansion of PHBs is changing existing practice whereby clinical commissioning groups commission a range of services from both the NHS, community sector and private providers. “If done correctly, PHBs can benefit people by offering a choice of affordable, quality, person-centred care that can significantly improve citizens’ health and wellbeing.”Baroness Campbell, who has been working closely on the issue with James Sanderson, director of personalised care for NHS England, also dismissed concerns that expanding PHBs was “privatisation by the back door”.She said that expanding PHBs could “help deliver independent living more effectively, by extending disabled people’s choice and control over the support they require to stay well and less reliant on hospital care and other health interventions.“This is inevitably a more cost-effective approach to supporting well-being – a major principal of the Care Act.”The government plans to outline its next steps in this summer’s adult social care green paper.The PHB consultation closes on 8 June.
Advertisement Africa’s gaming potential is to be explored and celebrated at WrB Africa, taking place on 11-12 April at The Sheraton Lagos Hotel, Nigeria.As part of the WrB Series run by Clarion Events, WrB Africa is the first ever summit dedicated to exploring the exciting opportunities and encouraging a regulatory framework that will produce a thriving and sustainable gaming industry in Sub-Saharan Africa.“We have launched WrB Africa for those seeking to unlock the huge potential of this region, but who may be unsure of the complexities of the regulatory environment. Perhaps they are already operating in one of the fast growing African regions but want to step up a level”, says Curtis Roach, senior conference producer on the event. – Advertisement – Delegates will be presented with a heavy-weight agenda and over 30 market-leading organisations to network with and to do business with, as well as the opportunity to learn directly from the leading companies based in East, West and Central Africa, in addition to the continent’s major regulators.The speaker line-up includes a keynote session from Lanre Gbajabiamila, chief executive of the Lagos State Lottery Board (LSLB).Other speakers include John Kamara, Director of Global Gaming Africa, Tarimba Abbas, Director General of Tanzania Gaming Board, Edward Lalumbe, COO of the Gauteng Gambling Board and Matthias Jacek Wojdyla, Head of International Affairs at FIFA.Gbajabiamila is optimistic about the continued growth of gambling in Lagos and Nigeria, with technology and the public’s appetite for sport among the driving forces.“The Nigerian gaming industry is an evolving one and gradually expanding. More states and individuals are becoming more aware of the opportunities that exist in the industry in terms of entertainment, revenue and employment.“We are really pleased to be associated with WrB Africa, it’s a great event that the market demands and I’m excited at the opportunities that it will create for the Sub-Saharan gaming industry.”Rory Credland, Event Director added: “It will be fantastic to bring together so many people from across the globe to talk about responsible gambling and how we can help to create a sustainable future for one of the Gaming industry’s high-potential markets.”WrB Africa is taking place at The Sheraton Lagos Hotel, Lagos, Nigeria, from April 11th – 12th in Lagos, Nigeria. More information including the agenda, speaker list and booking details is available at http://Africa.WrBriefing.com
Source:https://www.pasteur.fr/en/home/press-area/press-documents/aids-approach-targeting-hiv-reservoirs Reviewed by James Ives, M.Psych. (Editor)Dec 21 2018Current HIV treatments need to be taken for life by those infected as antiretroviral therapy is unable to eliminate viral reservoirs lurking in immune cells. Institut Pasteur scientists have identified the characteristics of CD4 T lymphocytes that are preferentially infected by the virus – it is their metabolic (or energy-producing) activity1 that enables the virus to multiply. Thanks to metabolic activity inhibitors, the researchers have managed to destroy these infected cells, or “reservoirs”, ex vivo. Their findings were published in the journal Cell Metabolism on December 20, 2018.Current HIV treatments need to be taken for life by those infected as antiretroviral therapy is unable to eliminate viral reservoirs lurking in immune cells. Institut Pasteur scientists have identified the characteristics of CD4 T lymphocytes that are preferentially infected by the virus – it is their metabolic (or energy-producing) activity that enables the virus to multiply. Thanks to metabolic activity inhibitors, the researchers have managed to destroy these infected cells, or “reservoirs”, ex vivo. Their findings were published in the journal Cell Metabolism on December 20, 2018.Related StoriesAlcohol reduction associated with improved viral suppression in women living with HIVHIV persists in spinal fluid even after long-term treatment and is linked to cognitive deficitsPrevalence of anal cancer precursors is higher in women living with HIV than previously reportedThe antiretroviral treatment used today is designed to block HIV infection but it is not able to eliminate the virus from the body. The virus remains in reservoirs – the CD4 T lymphocyte immune cells, the main targets of HIV. However, the virus does not infect all types of CD4 cell and until now the reason for this was not well known. In this study, scientists from the HIV, Inflammation and Persistence Unit at the Institut Pasteur and colleagues have identified the characteristics of the different CD4 subpopulations, which are associated with HIV infection.The more the CD4 cells are differentiated, or experienced, the more they need to produce energy to perform their function. Experiments have shown that it is the metabolic activity of the cell, and in particular its glucose consumption, that plays a key role in susceptibility to HIV infection. The virus primarily targets cells with high metabolic activity. To multiply, it hijacks the energy and products provided by the cell.This requirement constitutes a weakness for the virus and could be exploited to tackle infected cells. Scientists succeeded in blocking the infection ex vivo thanks to metabolic activity inhibitors that have already been investigated in cancer research.”We have observed ex vivo that, thanks to certain metabolic inhibitors, the virus is no longer able to infect cells and amplification is halted in reservoirs of patients receiving antiretroviral treatment.”Asier Saez-Cirion, coordinator of the studyThis research opens new ways towards possible remission through the elimination of reservoir cells. The next research phase will involve assessing the potential of these metabolic inhibitors in vivo.
By Sally Robertson, B.Sc.Apr 3 2019Reviewed by Kate Anderton, B.Sc. (Editor) The application of positron emission tomography (PET) for amyloid plaques could aid clinical decision making for patients with dementia or mild cognitive impairment (MCI), according to a study recently published in JAMA.Sebastian Kaulitzki | ShutterstockProfessor Gil Rabiovici (Department of Neurology, University of California) and colleagues found that among individuals with MCI or dementia, amyloid PET scanning was associated with changes in clinical management within ninety days.The study was conducted following a decision made in 2013 by the US Center for Medicare & Medicaid Services that current evidence was insufficient to justify the coverage of PET scanning in the routine clinical care of patients with MCI or dementia.However, the center also adhered to a policy of “Coverage with Evidence Development” among Medicare beneficiaries who meet the “Appropriate Use Criteria” for amyloid PET.Given that no disease-modifying treatments for cognitive impairment and dementia are currently available, the only way to assess patient outcomes in this population is to look at data relating to treatment decisions, counseling, and diagnosis.The Imaging Dementia—Evidence for Amyloid Scanning (IDEAS) study was an observational, longitudinal cohort study that included 11,409 Medicare beneficiaries (aged an average of 75 years) with dementia or MCI of unknown cause who were enrolled at 343 imaging centers in the US between February 2016 and September 2017.Ninety days after participants underwent amyloid PET scans, patient management changed compared with pre-PET visits in 60.2% of MCI patients and 63.5% of dementia patients, as assessed by a composite outcome that included drug therapy and counseling about safety and future planning.In addition, the etiologic diagnosis changed from Alzheimer disease to non-Alzheimer disease in 25.1% of cases and from non-Alzheimer disease to Alzheimer disease in 10.5% of cases.The authors note that the observational design of the study limits the attributing changes in patient management to the PET imaging results.Further research is therefore needed “to determine whether amyloid PET is associated with improved clinical outcomes,” concludes the team. Breaking news:5-minute read time. Sources:Jack CR, Petersen RC. Amyloid PET and Changes in Clinical Management for Patients With Cognitive Impairment. JAMA. 2019;321(13):1258–1260. DOI:10.1001/jama.2019.1998Rabinovici GD, Gatsonis C, Apgar C, et al. Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia. JAMA. 2019;321(13):1286–1294. DOI:10.1001/jama.2019.2000.
Reviewed by James Ives, M.Psych. (Editor)Jun 28 2019Early disease stages of MS are primarily characterized by immune cell infiltration of the CNS. This causes inflammation that damages the so-called myelin sheaths. Myelin sheaths are electrically insulating structures established by specialized glial cells of the CNS, referred to as ‘oligodendrocytes’. These structures protect, nourish and stabilize axons, which transmit electrical signals between neurons.There is a large therapeutic repertoire of immunomodulatory drugs available that can effectively target the inflammatory aspects of relapsing multiple sclerosis (RMS). But when MS progresses, damage accumulates which ultimately results in irreversible deficits and clinical disability. Unfortunately, despite decades of intense research disease progression is still untreatable as there are no therapies available that either prevent damage or repair injured axons.Related StoriesNovel imaging molecule reveals brain changes linked to progressive MSNerve transfer surgery restores upper limb function in people with tetraplegiaNanotechnology treatment reverses multiple sclerosis symptoms in miceIn a new study published online on June 18 in the renowned journal PNAS a research team led by Prof. Dr. Patrick Küry from the Department of Neurology (chaired by Prof. Dr. Hans-Peter Hartung) has shed light on a novel axon damage mechanism which could be highly relevant for progressive MS (PMS) patients.As outlined by the first author of this research paper, Dr. David Kremer, the envelope (ENV) protein of the pathogenic human endogenous retrovirus type W (pHERV-W) was found to be a major contributor to nerve damage in MS. In collaboration with research teams in Cleveland (OH, USA) and Montreal (CAN) the authors demonstrated that the ENV protein drives CNS resident microglial cells to contact and damage myelinated axons.Alongside the scientific research into determining how the damage mechanism works, clinical developments aiming at neutralizing the harmful ENV protein in MS patients have also progressed. Two clinical studies conducted under the supervision of Prof. Hartung have already successfully tested the ENV-neutralising antibody temelimab. MRI scans of the participants treated in the study showed reduced damage to the nerve tissue.The Düsseldorf-based researchers and their colleagues can therefore explain why neurodegeneration is decreased in patients treated with temelimab. This antibody specifically binds to the ENV protein of the retrovirus and blocks its activity in the CNS. As stated by Prof. Hartung, future clinical studies in progressive MS patients will now have to demonstrate whether temelimab treatment can also improve clinical symptoms resulting from neurodegeneration. Source:Heinrich-Heine University DuesseldorfJournal reference:Kremer, D. et al. (2019) pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis. PNAS. doi.org/10.1073/pnas.1901283116.